Bharath Sunchu

Postdoc

About Bharath

Bharath Sunchu

Bharath has a bachelor of pharmacy degree from Kakatiya University, India. He holds a masters degree from University of Dayton, Ohio, where he worked on bacterial DNA replication restart mechanism in the lab of Matthew Lopper. His PhD work in Viviana Perez’s lab at Oregon State University, Corvallis, focused on studying the differences in proteostasis between short- and long-lived species. His first post-doctoral research work was in Clemens Cabernard’s lab at the University of Washington, Seattle, where he studied the consequences of induced cell-cell fusion using the fly larval brain model. He is interested in studying the effects of nutrition on brain development.



Bharath's Projects


Nutrient-regulated neuronal circuits and insulin signaling

In Drosophila, there are 14 neurosecretory neurons located in the pars intercerebralis (the fly hypothalamus) that synthesize and secrete 3 of the 8 Drosophila insulin-like peptides (Dilps). Dilps bind to and activate the single Insulin-like tyrosine kinase receptor, which leads to downstream activation of the evolutionarily conserved PI3-kinase growth signaling pathway.

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Reactivation from quiescence

Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growth.

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